A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of Tramadol hydrochloride (TRA) and Diclofenac Sodium (DIC) by employing dual wavelength by using methanol as solvent. The two wavelengths for TRA were found to be 264nm and 281.51nm in and for DIC 270nm and 296.36nm in where respective drug gave same absorbance. The linearity was established over the concentration range of 2 - 16 μg/ml in and 5 - 25 μg/ml in for TRA and DIC respectively with correlation coefficient (r2) 0.9916 and 0.9972. The mean % recoveries were found to be in the range of 99.2 % - 99.73 and 99.33 – 99.64 % for TRA and DIC, respectively. The proposed method has been validated as per ICH guidelines and was successfully applied to the estimation of TRA and DIC in their combined Tablet dosage form.
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